Basic Information
VIS ID
TVIS10010260
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1765
Orient
-
Integrated sequence
TCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAG| |GTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGT
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
74366472/73656749 (Hg38)
End
74366472/73656749 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6D
Nearest miRNA
hsa-mir-10398/Upstream/688996; hsa-mir-10524/Downstream/1771658;
Nearest TSS
ENST00000381078/Upstream/2594; ENST00000474094/Downstream/39036;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/2466, chr6-CpG: 50/Downstream/39128
Nearby gene
SLC17A5(-2735) ; CD109(+39036) ;
Upstream sequence
gcagaagacatgaactcatccttttttatggctgcatagtattccatggtgtatatgtgccacattttcttaatccagtctatcattgatggacatttgg
Downstream sequence
actgtgaagttaactcttttcccccggccttacttttctctttggaaggaaatcagtatgtgcagccttcacttaaggggtggggagttatctatactcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate