Basic Information
VIS ID
TVIS10010262
Fusion event
HBV-LOC101928570 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2184
Orient
+
Integrated sequence
CTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGC| |CTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCA
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
77823626/77113909 (Hg38)
End
77823626/77113909 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC101928570
Nearest miRNA
hsa-mir-10398/Upstream/1685436; hsa-mir-10524/Downstream/1425354;
Nearest TSS
ENST00000381078/Upstream/338926; ENST00000602452/Downstream/349864;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1364359, chr6-CpG: 132/Downstream/348605
Nearby gene
IMPG1(-1041291) ; HTR1B(+348322) ;
Upstream sequence
GTTTGTGACTGGAGTGCTACCTGAGTAAATTATCATGATTACATGAAAAGCAATTAAGAGAAGAAGGTCAAAGGACCAACCTCTAATCACTAAGTTTGGT
Downstream sequence
TAAACCTCAGGGAAAAAGAAACAGAACACATAATTCAGGGCCATTGTTAACTGAGTTGAATTTTGAAAAAAATAAAGTTGCCCCAAATATCTTCTTATCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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