Basic Information
VIS ID
TVIS10010264
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1814
Orient
-
Integrated sequence
GACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCAC| |CATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGAC
Host Sequence
Chromosome
chr7
Cytoband
q31.33
Reference genome
GRCh37/hg19
Start
124901164/125261110 (Hg38)
End
124901164/125261110 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC101928254 ; LOC101928283
Nearest miRNA
hsa-mir-10525/Upstream/8240791; hsa-mir-10399/Downstream/1796978;
Nearest TSS
ENST00000635602/Upstream/88892; ENST00000453278/Downstream/3181;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/330965, chr7-CpG: 237/Downstream/1990136
Nearby gene
POT1(-331127) ; GRM8(+1177488) ;
Upstream sequence
acagagcgagactccatctcaaaaacaaaacaaaaattacccaggcatggtggcatgctcctgtagtcccagctatttgggaggctgaggcaggaggact
Downstream sequence
aggaaaggagttgttgttttgtagaaggtgctggggtttgagagatcagtcggacaagattggcagggagagcacgtgtgtttttatgagaattatgccg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate