ETV1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010266
Fusion event
HBV-ETV1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1781
Orient
-
Integrated sequence
ATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAG| |GCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTG
Host Sequence
Chromosome
chr7
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
13933428/13893803 (Hg38)
End
13933428/13893803 (Hg38)
Orient
+
Location type
UTR3
Target gene
ETV1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-339/Upstream/6826758; hsa-mir-10399/Downstream/4233417;
Nearest TSS
ENST00000635602/Upstream/34778; ENST00000412014/Downstream/12695;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1206180, chr7-CpG: 18/Downstream/95950
Nearest cancer related gene
ETV1(OG, No orient, 0)
Upstream sequence
acagagcaagactccatctcaaaaacaaaacaaaaattacccaggcatggtggcatgctcctgtagtcccagctatttgggaggctgaggcaggaggact
Downstream sequence
GTAGATGGCCACATAAGCATAGTGGGGAGAAAAGGTTCTGATTTTTAAGGCATAGTTTTCTTTTTTAGGCCCAAAATGGGCCAAAATAATACATGATGTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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