Basic Information
VIS ID
TVIS10010268
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1799
Orient
-
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr7
Cytoband
q36.3
Reference genome
GRCh37/hg19
Start
158757917/158965226 (Hg38)
End
158757917/158965226 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA7I
Nearest miRNA
hsa-mir-10399/Upstream/373530;
Nearest TSS
ENST00000635602/Upstream/31033; ENST00000377633/Downstream/131978;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/5201, chr7-CpG: 113/Downstream/8209
Nearby gene
WDR60(-19034) ; LINC00689(+43128) ;
Upstream sequence
ctttctttctttctctctttcttttctttcttttttttttttttttttttttttttttAAAAAAAAAAAGGGGttttttttttttttttttttttttttt
Downstream sequence
agactggggagtttataaaggaaagaggtttaattgaatcatagttccacatggctggggaggcctcaggaaacttacaatcatggtagaaggggaagta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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