VISDB Viral Integration Site DataBase

VIS ID

TVIS10010269

Fusion event

HBV-CREB5 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1984

Orient

+

Integrated sequence

CTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTAC| |GAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTG

Chromosome

chr7

Cytoband

p15.1

Reference genome

Start

End

28506109/28466491 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-125a-5p ; hsa-mir-10a-5p ; hsa-mir-32-5p ; hsa-mir-6832-3p ; hsa-mir-182-5p ; hsa-mir-8485 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-1179 ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-147a ; hsa-mir-29b-2-5p ; hsa-mir-155-3p ; hsa-mir-6867-5p ; hsa-mir-644a ; hsa-mir-3911 ; hsa-mir-1273g-5p ; hsa-mir-203a-5p ; hsa-mir-92a-1-5p ; hsa-mir-374c-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-323b-3p ; hsa-mir-5195-5p ; hsa-mir-651-3p ; hsa-mir-590-5p ; hsa-mir-29c-3p ; hsa-mir-449a ; hsa-mir-128-3p ; hsa-mir-216a-3p ; hsa-mir-3681-3p ; hsa-mir-4672 ; hsa-mir-6768-5p

Nearest miRNA

hsa-mir-1183/Upstream/1296928; hsa-mir-10399/Downstream/1214243;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/56538, chr7-CpG: 53/Downstream/387345

Upstream sequence

AACTTAATTGAGAGAAAAAATCACGTGTGGCATTTGTAGCAGGAGGTATGAGCTCAGTGAAATAAAAAAGTTAACTTTGTAATCACATACCCAGGTACAC

Downstream sequence

aaatactttttcagtagggttgtggtgaggactaagtCAACGGCAATAAATCTGAGTTGCCTTCTCTTCCTTCTTTCTGACTAAGCTTTTCGTGTCACAA