hsa-mir-130b-3p _LIHC.png
PPP1R9A _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010272
Fusion event
HBV-PPP1R9A integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2089
Orient
+
Integrated sequence
CTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGG| |GGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAA
Host Sequence
Chromosome
chr7
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
94823552/95194240 (Hg38)
End
94823552/95194240 (Hg38)
Orient
+
Location type
Intronic
Target gene
PPP1R9A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-130b-3p ; hsa-mir-33a-5p ; hsa-mir-181a-5p ; hsa-mir-3121-3p
Nearest miRNA
hsa-mir-10525/Upstream/1477235; hsa-mir-10399/Downstream/1025422;
Nearest TSS
ENST00000635602/Upstream/284157; ENST00000608730/Downstream/20092;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/286075, chr7-CpG: 19/Downstream/130217
Upstream sequence
gtttcaaacatgctaaatgtaagatgccagttagacagccacggagaaatattgaacagagagttatacagatatatatatatatatatatatatatata
Downstream sequence
AATGAATTCAAGGTAGTCATTATATGTCTATGGATTCTTTAAGCATGTTAAAGACTTTATGTATCTTTAACCATAAAAAACATAATATTGCTAAATAAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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