VISDB Viral Integration Site DataBase

VIS ID

TVIS10010275

Fusion event

HBV-PINX1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1799

Orient

-

Integrated sequence

GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG

Chromosome

chr8

Cytoband

p23.1

Reference genome

Start

End

10642067/10784557 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-331-3p ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-5683 ; hsa-mir-8485 ; hsa-mir-5589-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4279 ; hsa-mir-6881-3p ; hsa-mir-642a-5p ; hsa-mir-6845-3p ; hsa-mir-877-3p ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-208b-5p ; hsa-mir-208a-5p

Nearest miRNA

hsa-mir-124-1/Upstream/117487; hsa-mir-10400/Downstream/40816;

Nearest TSS

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/50958, chr8-CpG: 75/Downstream/54861

Nearest cancer related gene

PINX1(TSG, No orient, 0)

Upstream sequence

cagagacatgaaaaacccttcaaaaatcaatgaatccaggaggtgtttttttgaaaagattaacaaaatagatagaccactagccagactaataaagaag

Downstream sequence

TTCCTAAGTTAGCTTTTCTGCTTGCAGAAAAATAAACCTCACAAAACCTAGTTTACTGAAAGGCATAAAGTAAGTTTAAGCACTTGTTAAAAAGCTATTT