Basic Information
VIS ID
TVIS10010276
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1796
Orient
-
Integrated sequence
CTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAAT| |TGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTT
Host Sequence
Chromosome
chr8
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
113171029/112158800 (Hg38)
End
113171029/112158800 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/7674335; hsa-mir-10400/Downstream/484693;
Nearest TSS
ENST00000518652/Upstream/413282; ENST00000521500/Downstream/97128;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/2182957, chr8-CpG: 21/Downstream/1273797
Nearby gene
CSMD3(+64130) ;
Upstream sequence
TGGGCCGTAAAATGGAATTAAGCTGACTTCTCAAAGCCAATTGATCTAAAGACAAATCCTAGCAACTCAACAGACCACAGATATTATCTGTTTACAAAAT
Downstream sequence
CAATTTATCAATATGTTCAATGGTCAGAGAGGAGTTTTTAGAAAGAATGGGGATAATTAATTCTGACAAAGAACATTCTTAAATTCAAATGACAGAATGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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