Basic Information
VIS ID
TVIS10010280
Fusion event
HBV-LOC401478 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2061
Orient
+
Integrated sequence
TTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACT| |GCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCA
Host Sequence
Chromosome
chr8
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
138837614/137825371 (Hg38)
End
138837614/137825371 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC401478
Nearest miRNA
hsa-mir-1204/Upstream/3020426; hsa-mir-10400/Downstream/2907193;
Nearest TSS
ENST00000518652/Upstream/1028098; ENST00000519652/Downstream/26956;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/2367272, chr8-CpG: 119/Downstream/671181
Nearby gene
FAM135B(+304652) ;
Upstream sequence
gtattaccttctaaaatatttaaaatggtattcccgccccctcccccctccgccacatttaggtctttaatctaccagtttttaaaaatatggtgtgaga
Downstream sequence
gggaggacctaggacatctaattagagagtgcctaaggaggttcagcatagccttgccagcaaagattatttatttacttcaagagttcagagtggcagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate