Basic Information
VIS ID
TVIS10010281
Fusion event
HBV-LOC401478 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1815
Orient
-
Integrated sequence
ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chr8
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
138945293/137933050 (Hg38)
End
138945293/137933050 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC401478
Nearest miRNA
hsa-mir-1204/Upstream/3128105; hsa-mir-10400/Downstream/2799514;
Nearest TSS
ENST00000518652/Upstream/80723; ENST00000521793/Downstream/130218;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/2474951, chr8-CpG: 119/Downstream/563502
Nearby gene
FAM135B(+196973) ;
Upstream sequence
ttTAAGGTGTAAGTAACTAGTAATAAAGTGAATGAGCtgtgatacgggggaaagaatacagtagtagggcaagaagaaaaaataattggattaagttcca
Downstream sequence
ctcCTTGGTCAGTGAGACAGGATCACCCTGACTGAagcattccccctcaccttattttcttgctttatttttcttcttaggaactatcaacaccacatat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate