Basic Information
VIS ID
TVIS10010287
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1798
Orient
-
Integrated sequence
TGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTG| |GTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTG
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
93402197/92389969 (Hg38)
End
93402197/92389969 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/1184410; hsa-mir-10400/Downstream/639782;
Nearest TSS
ENST00000518652/Upstream/286683; ENST00000522531/Downstream/23676;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/245557, chr8-CpG: 56/Downstream/575596
Nearby gene
RUNX1T1(-286743) ; FLJ46284(+322993) ;
Nearest cancer related gene
RUNX1T1(OG, -286743) ;
Upstream sequence
gcctctgtgacagagcaagactctgttaaaaaaaaaaaaaaaaaaaaaaaagaaaagaaaagaaaagaaagaaaaaaacgaaaaatatctatcagtgcaa
Downstream sequence
AATAGTTAAACATTTTTTAGTTGGTGGGGGGGGCAGTTTAACCTTAAAAGTCTAAATAATTATGAAAACTTAAAACAAGATAGATTGAATATCAAAAGAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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