Basic Information
VIS ID
TVIS10010289
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1799
Orient
-
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
104648469/101886187 (Hg38)
End
104648469/101886187 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7a-1/Upstream/3656970; hsa-mir-12126/Downstream/4714741;
Nearest TSS
ENST00000422679/Upstream/147607; ENST00000374801/Downstream/633449;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/147393, chr9-CpG: 38/Downstream/2113162
Nearby gene
GRIN3A(-147607) ; CYLC2(+1109124) ;
Upstream sequence
ttttggaataggtgtggtgtggtgttgaaaaaaatgtgtattctgttgatttggggtggagagttctgtagatgtctattatgtctgcttggtgcagagc
Downstream sequence
AAATATCTGGGTGAACTGTTATAAAACACAAAGAACTTTCAACTTTTCGAAGGAAAAATACAAACAGAAACCATTTTTTTTCTTATAGGAAGTATGTCCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate