VISDB Viral Integration Site DataBase

VIS ID

TVIS10010290

Fusion event

HBV-ZNF483 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2404

Orient

+

Integrated sequence

CCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGT| |CTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTA

Chromosome

chr9

Cytoband

q31.3

Reference genome

Start

End

114291580/111529300 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-331-3p ; hsa-mir-125b-5p ; hsa-mir-544a ; hsa-mir-541-5p ; hsa-mir-7156-3p ; hsa-mir-1184 ; hsa-mir-4469 ; hsa-mir-4655-3p ; hsa-mir-6803-3p ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418

Nearest miRNA

hsa-let-7a-1/Upstream/258086; hsa-mir-12126/Downstream/402800;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/44796, chr9-CpG: 84/Downstream/101766

Upstream sequence

gcccagctaatttttgaatttctagtagagacaggatttccccatgttggccaggctggtcttgaactcctgacctcaagtgatccacctgccttggcat

Downstream sequence

TGAAAAAATAATTTTTCTTAATTGAAAAAGAGCTGTTGACATCCGAGGGTTTTTATGTATGTATTTTTtactgctccttgtggagcagggatcactcata