Basic Information
VIS ID
TVIS10010291
Fusion event
HBV-SHOC1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr9
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
114459963/111697683 (Hg38)
End
114459963/111697683 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9E
Target gene
SHOC1
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-let-7a-1/Upstream/426469; hsa-mir-12126/Downstream/234417;
Nearest TSS
ENST00000422679/Upstream/36348; ENST00000489355/Downstream/61850;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/35655, chr9-CpG: 22/Downstream/97324
Upstream sequence
agagaccgtggaaagagagggagagggagaccgtggggagagggagagggagagggagagggagagggagagggagagggagagggagagggagagggag
Downstream sequence
tataatcctttgggtatatacccagtaatggtatggctgggtcaaatggtatttctagttctagatcctagaggaatcgccacactgtcttccacaatgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate