VISDB Viral Integration Site DataBase

VIS ID

TVIS10010294

Fusion event

HBV-MEGF9 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1827

Orient

-

Integrated sequence

AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT

Chromosome

chr9

Cytoband

q33.2

Reference genome

Start

End

123462328/120700050 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-151a-3p ; hsa-mir-21-5p ; hsa-mir-877-5p ; hsa-mir-197-3p ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-222-3p ; hsa-mir-432-5p

Nearest miRNA

hsa-let-7a-1/Upstream/455000; hsa-mir-12126/Downstream/1420032;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/119815, chr9-CpG: 138/Downstream/13657

Upstream sequence

atcccatttgtcaattttggcttttgttgccattgcttttggtgttttagacatgaagtccttgcccatgcctatgtcctgaatggtattgtctaggttt

Downstream sequence

ATAAACCATGTAACTTGGAAAGAATATTAAAGCCTTTATGTCTGAGAAAGCCCAAAGTAGTTTACATGTGTTACTTCTCAAAAACCTTTGGTGACTGGAA