Basic Information
VIS ID
TVIS10010298
Fusion event
HBV-ANKRD18CP integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1928
Orient
+
Integrated sequence
ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT| |TGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTA
Host Sequence
Chromosome
chr9
Cytoband
q22.33
Reference genome
GRCh37/hg19
Start
99955830/97193548 (Hg38)
End
99955830/97193548 (Hg38)
Orient
+
Location type
Intronic
Target gene
ANKRD18CP
Nearest miRNA
hsa-let-7a-1/Upstream/2107454; hsa-mir-12126/Downstream/170006;
Nearest TSS
ENST00000422679/Upstream/153905; ENST00000420204/Downstream/4139;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/72067, chr9-CpG: 23/Downstream/6306
Nearby gene
GAS2L1P2(-111603) ; SUGT1P4-STRA6LP(+44878) ;
Upstream sequence
agccactgcacctggcctaggatcacacagttcttaagtggtagagctaggatttgaacccaggcagtctggcttcagaaatcatgctcttgaccactgc
Downstream sequence
TGTGGCTAGAGCCAGGAGGCCTCGCTGCCAGAGCAGGGTGCTGGGAACAATGGCTGAGCCTATGTACATGAACTAAAAAACACTGTAGCTGTGggctggg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate