Basic Information
VIS ID
TVIS10010309
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
26
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCT| |GCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATC
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
248873416/248710115 (Hg38)
End
248873416/248710115 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1I
Nearest miRNA
hsa-mir-101-1/Upstream/1508055; hsa-mir-3124/Downstream/116262;
Nearest TSS
ENST00000473358/Upstream/27811; ENST00000515369/Downstream/35164;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/17946, chr1-CpG: 138/Downstream/36468
Nearby gene
OR14I1(-27811) ; LYPD8(+29301) ;
Upstream sequence
tttttttttttttttaagacagggtctcactctgtcacccaagctggagtgcagtggtgcaatcagctcactgtaacctcaatctcttgggttcaagcgg
Downstream sequence
tcctcctgcctcagcctcccaaatagctgggcctacaggcacacgccaccattcctggctaatctcattgtggttttgatttgcatttccgtggtggcta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate