VISDB Viral Integration Site DataBase

VIS ID

TVIS10010314

Fusion event

HBV-SLC25A33 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1820

Orient

+

Integrated sequence

TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT

Chromosome

chr1

Cytoband

p36.22

Reference genome

Start

End

9640669/9580611 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-193b-3p ; hsa-mir-92a-3p ; hsa-mir-1304-5p ; hsa-mir-582-5p ; hsa-mir-101-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-655-5p ; hsa-mir-610 ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4433a-3p ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-6794-3p ; hsa-mir-4294 ; hsa-mir-1289 ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-1273f ; hsa-mir-4708-5p ; hsa-mir-6088 ; hsa-mir-4770 ; hsa-mir-143-3p ; hsa-mir-1304-3p ; hsa-mir-4639-3p ; hsa-mir-6514-5p ; hsa-mir-5698 ; hsa-mir-7108-5p ; hsa-mir-663b ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-566 ; hsa-mir-7155-3p ; hsa-mir-6789-3p ; hsa-mir-3136-3p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-134-3p ; hsa-mir-7114-5p ; hsa-mir-6787-3p ; hsa-mir-5693 ; hsa-mir-6736-3p ; hsa-mir-3115 ; hsa-mir-6741-5p ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-2276-3p ; hsa-mir-4485-5p ; hsa-mir-6890-3p ; hsa-mir-4279 ; hsa-mir-5089-5p ; hsa-mir-5001-3p ; hsa-mir-1268b ; hsa-mir-1268a ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-512-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-4677-5p ; hsa-mir-943 ; hsa-mir-22-5p ; hsa-mir-2116-5p ; hsa-mir-6716-5p ; hsa-mir-26b-3p

Nearest miRNA

hsa-mir-12136/Upstream/428834; hsa-mir-101-1/Downstream/386770;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/40226, chr1-CpG: 119/Downstream/8063

Upstream sequence

ctggattgtatttaatattccttgaatcaaaatgataatatgggagccaaaCTTACTCAGCCTCggcggggcacggtggctcacgcctgtaatcccagca

Downstream sequence

ctttgggaggctgaggcgggcggatcatgaggtcaagggattgagaccagcctggccaacatggtgaaaccccgtctctactaaaaatacaaaaattagc