VISDB Viral Integration Site DataBase

VIS ID

TVIS10010315

Fusion event

HBV-ZRANB1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1639

Orient

-

Integrated sequence

ACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATA| |TTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGG

Chromosome

chr10

Cytoband

q26.13

Reference genome

Start

End

126645297/124956728 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA10D ; FRA10F ; FRA10A ; FRA10B

Target gene

miRNAs that regulate target gene

hsa-mir-103a-3p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-16-1-3p ; hsa-mir-513a-3p ; hsa-mir-770-5p ; hsa-mir-513c-3p ; hsa-mir-1912 ; hsa-mir-2681-5p ; hsa-mir-3130-5p ; hsa-mir-3606-3p ; hsa-mir-4482-5p ; hsa-mir-1295b-5p ; hsa-mir-136-3p ; hsa-mir-6083 ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-6846-3p ; hsa-mir-6859-3p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-5591-3p ; hsa-mir-3144-3p ; hsa-mir-875-5p ; hsa-mir-6867-5p ; hsa-mir-574-5p ; hsa-mir-933 ; hsa-mir-892a ; hsa-mir-548g-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-4783-5p

Nearest miRNA

hsa-mir-107/Upstream/2539661; hsa-mir-202/Downstream/76055;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/39085, chr10-CpG: 26/Downstream/41254

Upstream sequence

cccagctcatatttgtgttttttagtaatggcggggtttcaccatgttggctaggctggtctcgaactcctgacctcaagtgatccacctgccttggcat

Downstream sequence

cccaaagtgcttggattacaggcatgaaccaccatgcctggccCCTGTCAttattttataatgagaaatttcaaaacctgtataaaggttacaagtgtaa