Basic Information
VIS ID
TVIS10010317
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
26
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCT| |GCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATC
Host Sequence
Chromosome
chr10
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
30426151/30137222 (Hg38)
End
30426151/30137222 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/534876; hsa-mir-107/Downstream/231375;
Nearest TSS
ENST00000439456/Upstream/21728; ENST00000375322/Downstream/211755;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/77503, chr10-CpG: 26/Downstream/211810
Nearby gene
JCAD(-77663) ; MTPAP(+172579) ;
Upstream sequence
ttaagaaacagggtcttgctctgtcacccaggctggagtactggagtacagtggtacaatcatagctcactgaagccttgaactagtggggtcaagcaat
Downstream sequence
cctcctgcctcagcctcccaaatagctgggactataggcacagaccaccacacctggataattttttaatttttattttgtagagatggaggccttgcta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate