Basic Information
VIS ID
TVIS10010319
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2160
Orient
+
Integrated sequence
TGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTC| |AGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGG
Host Sequence
Chromosome
chr10
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
38805378/38516450 (Hg38)
End
38805378/38516450 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/2875198; hsa-mir-107/Downstream/4481113;
Nearest TSS
ENST00000439456/Upstream/63269; ENST00000442306/Downstream/3668889;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/65674, chr10-CpG: 103/Downstream/83805
Nearby gene
LINC00999(-64297) ; ACTR3BP5(+184349) ;
Upstream sequence
tggattcaaatggaagggaatggaatggaatggacccgaatggaatgcaatgtagccaatctgaatggactcgaaaggaaagcaatgtagagaaatgata
Downstream sequence
tggacacgaatggaatggaatggaatggaatgaaatggactcaaatggaatggaaactaatggcatgaaacggaatgcaatggaacggaatggaatggaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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