Basic Information
VIS ID
TVIS10010331
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1819
Orient
+
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
106570972/106177194 (Hg38)
End
106570972/106177194 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/1585478; hsa-mir-1178/Downstream/2458616;
Nearest TSS
ENST00000382841/Upstream/37161; ENST00000611145/Downstream/70794;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/37276, chr12-CpG: 19/Downstream/62450
Nearby gene
NUAK1(-37161) ; CKAP4(+60687) ;
Nearest cancer related gene
NUAK1(TSG, -37161) ;
Upstream sequence
ctggctaatttttgtatttttagtagagacagggtttcaccgtgttggccaggatggtctcgatttcttaaccttgtggtccgcccacctccacctccca
Downstream sequence
aagtgctgggattacaggcgtgagccaccgtgccccgccTGTCTCCCATCCTAATGGTGGAGTAGCGCTCCACCATTGCCTCCTCACCCACTCCTCCAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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