VISDB Viral Integration Site DataBase

VIS ID

TVIS10010338

Fusion event

HBV-CACNA1C integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

1363

Orient

-

Integrated sequence

CGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATA| |TACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCT

Chromosome

chr12

Cytoband

p13.33

Reference genome

Start

End

2250351/2141185 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-133a-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-4780 ; hsa-mir-6780b-3p ; hsa-mir-3938 ; hsa-mir-6791-5p ; hsa-mir-6778-5p ; hsa-mir-450a-2-3p ; hsa-mir-6857-5p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-6810-5p ; hsa-mir-2110 ; hsa-mir-3147 ; hsa-mir-4425 ; hsa-mir-185-3p ; hsa-mir-4283 ; hsa-mir-4489 ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-5001-5p ; hsa-mir-762 ; hsa-mir-4498 ; hsa-mir-4492 ; hsa-mir-7106-5p ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-4731-5p ; hsa-mir-6754-5p ; hsa-mir-4487 ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-29a-3p ; hsa-mir-208a-3p ; hsa-mir-208b-3p ; hsa-mir-103a-3p

Nearest miRNA

hsa-mir-3649/Upstream/480805; hsa-let-7i/Downstream/4822514;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/25706, chr12-CpG: 42/Downstream/88811

Upstream sequence

agcagggccaggaccccgaggtgagcagggcccactgtggctgctgctcaggaggggagatgaaggaggatgtgagtggggttggaggggcagacagggg

Downstream sequence

ctgaattatgtggGTCAGCATGAGGAGTTTGTTGTGAGTGTGACGTTGGCAGGTCTGTGTGCTTCCCAAGGCTCCAGAGGAGCAGGAAGGATCTGGAGGA