VISDB Viral Integration Site DataBase

VIS ID

TVIS10010339

Fusion event

HBV-RASSF8 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

1033

Orient

+

Integrated sequence

AAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTAC| |ACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAA

Chromosome

chr12

Cytoband

p12.1

Reference genome

Start

End

26228833/26075900 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-130b-3p ; hsa-mir-9-5p ; hsa-mir-148a-3p ; hsa-mir-192-5p ; hsa-mir-629-5p ; hsa-mir-19a-5p ; hsa-mir-19b-1-5p ; hsa-mir-19b-2-5p ; hsa-mir-219a-5p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-429 ; hsa-mir-511-5p ; hsa-mir-508-3p ; hsa-mir-1245a ; hsa-mir-2052 ; hsa-mir-3121-3p ; hsa-mir-4427 ; hsa-mir-4445-5p ; hsa-mir-4724-5p ; hsa-mir-4782-3p ; hsa-mir-6766-3p ; hsa-mir-8062 ; hsa-mir-8079 ; hsa-mir-6830-3p ; hsa-mir-224-5p

Nearest miRNA

hsa-mir-1244-3/Upstream/201821; hsa-let-7i/Downstream/16247800;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/116510, chr12-CpG: 59/Downstream/38225

Nearest cancer related gene

RASSF8(TSG, No orient, 0)

Upstream sequence

ACACAAAGGGAGGCTGGGGAGACAGGGAGGAGTGCGGCATGTACACCAGGAACAACTCACTCAGGCAAGGGAGGGGCTCACCAGAGAAGCCACTGTGACA

Downstream sequence

GTCATTGGGCACAGCCACAAACTGctcctacatcaccccaccaacgccagcctacatctgaatcctttgagggccacaccatcccagcccatctcgacaa