VISDB Viral Integration Site DataBase

VIS ID

TVIS10010348

Fusion event

HBV-TEAD4 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2634

Orient

-

Integrated sequence

CACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATT| |GATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTC

Chromosome

chr12

Cytoband

p13.33

Reference genome

Start

End

3098319/2989153 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-98-5p ; hsa-mir-181a-5p ; hsa-mir-512-5p

Nearest miRNA

hsa-mir-3649/Upstream/1328773; hsa-let-7i/Downstream/3974546;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/28875, chr12-CpG: 91/Downstream/87692

Upstream sequence

ccacctatagctggtgggtcagaagcacaggtaaaacaacccagggcatgggattggcatgggaagtcgggaggcagtcctgtggaaccgagcccccacc

Downstream sequence

ctgtgggatctcctggcttcaagcaaccctcctgcctctcggcctcccaaagtgctgagattataggtatgagccaccatgcccagccCTGATTTTCTCA