Basic Information
VIS ID
TVIS10010352
Fusion event
HBV-LOC105369617 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1858
Orient
-
Integrated sequence
GTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTC| |CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTT
Host Sequence
Chromosome
chr12
Cytoband
p13.31
Reference genome
GRCh37/hg19
Start
5430048/5320882 (Hg38)
End
5430048/5320882 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105369617
Nearest miRNA
hsa-mir-3649/Upstream/3660502; hsa-let-7i/Downstream/1642817;
Nearest TSS
ENST00000382841/Upstream/4921; ENST00000537714/Downstream/46892;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/177478, chr12-CpG: 56/Downstream/109847
Nearby gene
KCNA5(-274094) ; NTF3(+111232) ;
Upstream sequence
agtactggaagtcctaacaaaagcaattaggcaaaagaaataaagaacatccaaattggaaagagtgaagtagaattgcacctgtttgcagataacatca
Downstream sequence
tcttatatgtagaaaaacctaaagatttcaacaaaaaactcttagaactgataaatttagtaaagtaggagaatacaaaaatcaacatacaaaatcagta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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