Basic Information
VIS ID
TVIS10010353
Fusion event
HBV-LOC105369617 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2801
Orient
+
Integrated sequence
TATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATA| |GCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACC
Host Sequence
Chromosome
chr12
Cytoband
p13.31
Reference genome
GRCh37/hg19
Start
5432581/5323415 (Hg38)
End
5432581/5323415 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105369617
Nearest miRNA
hsa-mir-3649/Upstream/3663035; hsa-let-7i/Downstream/1640284;
Nearest TSS
ENST00000382841/Upstream/7454; ENST00000537714/Downstream/44359;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/180011, chr12-CpG: 56/Downstream/107314
Nearby gene
KCNA5(-276627) ; NTF3(+108699) ;
Upstream sequence
tttacactcccaccaacagtgtaaaagcgttGATAGGAGGAATAAGTTCTAATGCCCTATCACACCTTGTGTGACTTCTTCAAAATGTTATCTACTATCT
Downstream sequence
CTATTCTTTTCTTCCCATTATAATTCCCTTGGGAGAGAATTCTCCAATTTACTGTAACACACATCTTACTGATTAGGTTTAATGCTACACTCCTTCAAGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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