Basic Information
VIS ID
TVIS10010367
Fusion event
HBV-LOC105370301 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2132
Orient
+
Integrated sequence
CTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGA| |AGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTT
Host Sequence
Chromosome
chr13
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
87696849/87044594 (Hg38)
End
87696849/87044594 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105370301
Nearest miRNA
hsa-mir-1297/Upstream/9346478; hsa-mir-1267/Downstream/574071;
Nearest TSS
ENST00000623511/Upstream/132676; ENST00000325089/Downstream/402641;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/3164832, chr13-CpG: 121/Downstream/626720
Nearby gene
SLITRK6(-1323366) ; MIR4500HG(+399393) ;
Upstream sequence
acaacacacaaaaacgctttaaaaattagtgaatccaggagctgttttttttgaaaagattgacaaaatagatagaccgctagccagactaataaagaag
Downstream sequence
aaaagagagaagaatcatatagacacaataaaaaatgataaaagggatgtcaccattgatcccacagaaatacaaactaccatcagagaatactataaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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