Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10010371
Fusion event
HBV-ERH integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|middle S protein|
Start
26
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCT| |GCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATC
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
Start
End
69860652/69393935 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-mir-4709-3p ; hsa-mir-1257 ; hsa-mir-340-5p ; hsa-mir-3185 ; hsa-mir-4635 ; hsa-mir-4501 ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-3154 ; hsa-mir-8054 ; hsa-mir-548l ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-3935
Nearest miRNA
hsa-mir-208a/Upstream/1952005; hsa-mir-1185-1/Downstream/3122885;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/132259, chr14-CpG: 44/Downstream/4061
Upstream sequence
acacagtgaccccatctctataaaaaaaccaaaaaattagccaggtgtggcggcaggtgcctctagtcccagctatttgggaggctgaggcaggaggact
Downstream sequence
gcttgagcccaggaaactgagactgcaataagccattatcaccactgtaccccagcctgggtgacagagcaagaccccgtgtcttaaggaaaaaaaaaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.