Basic Information
VIS ID
TVIS10010374
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1819
Orient
+
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr15
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
30799205/30507002 (Hg38)
End
30799205/30507002 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1268a/Upstream/2016157; hsa-mir-10393/Downstream/558030;
Nearest TSS
ENST00000557528/Upstream/92840; ENST00000562992/Downstream/33091;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/35410, chr15-CpG: 90/Downstream/65424
Nearby gene
CHRFAM7A(-113341) ; ULK4P1(+65553) ;
Upstream sequence
aaataaataaataaacaaataaataaataaaGCCTATTTTATAAAAAAGAAAAATTCAgccgggcacggtggctcacgcctgtaatcccagcactttttt
Downstream sequence
gggaggccgaggtgggtggatcatgaggtcaggagatccagaccatcctgactaacatgagtgaaaGAATGGAGTGGTATATAATGTAGCAGAGTTGATA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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