Basic Information
VIS ID
TVIS10010377
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1639
Orient
-
Integrated sequence
ACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATA| |TTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGG
Host Sequence
Chromosome
chr15
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
74824567/74532226 (Hg38)
End
74824567/74532226 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/120794; hsa-mir-11181/Downstream/256446;
Nearest TSS
ENST00000557528/Upstream/42624; ENST00000569680/Downstream/8951;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/70588, chr15-CpG: 76/Downstream/8674
Nearby gene
UBL7-AS1(-50934) ; ARID3B(+8981) ;
Upstream sequence
CCATTTACCCGTTGTTTCTTAGCTTTTATGCACTGTACATTTAAGACTAAATTTAggccaggctcagtggctcacacttgtaatcccagcactttgagat
Downstream sequence
gccaaggcaggtggatcacttgaggtcaggagttcaagaccaccctggccaacatggcgaaaccctatctctactaaaaatacaaaaaaaaaattggtca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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