Basic Information
VIS ID
TVIS10010379
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1639
Orient
-
Integrated sequence
ACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATA| |TTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGG
Host Sequence
Chromosome
chr16
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
10434971/10341114 (Hg38)
End
10434971/10341114 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/4708548; hsa-mir-11401/Downstream/965326;
Nearest TSS
ENST00000527434/Upstream/14680; ENST00000570163/Downstream/11638;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/88706, chr16-CpG: 59/Downstream/44715
Nearby gene
GRIN2A(-158360) ; ATF7IP2(+44941) ;
Nearest cancer related gene
GRIN2A(TSG, -158360) ;
Upstream sequence
tctgtcacaaaaaaaaaaaaaaaaaaaaaaaaaaacctattttaaaaagtatacaggtcaggtgtggtggcttacacctggaatcccagcactttgggat
Downstream sequence
gccaaggcaggtggatcacttgaggtcaggagttcaagaccagactggcccacatggtaaaaccccatctctactaaaaattaccaaaaaaatattagcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate