VISDB Viral Integration Site DataBase

VIS ID

TVIS10010383

Fusion event

HBV-RPA1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1819

Orient

+

Integrated sequence

TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA

Chromosome

chr17

Cytoband

p13.3

Reference genome

Start

End

1744119/1840825 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1301-3p ; hsa-mir-615-3p ; hsa-mir-339-5p ; hsa-mir-31-5p ; hsa-let-7e-5p ; hsa-mir-145-5p ; hsa-mir-30a-5p ; hsa-mir-133a-5p ; hsa-mir-138-5p ; hsa-mir-139-3p ; hsa-mir-29b-1-5p ; hsa-mir-29b-2-5p ; hsa-mir-5091 ; hsa-mir-5092 ; hsa-mir-6131 ; hsa-mir-6863

Nearest miRNA

hsa-mir-22/Upstream/126838; hsa-mir-10226/Downstream/209083;

Nearest TSS

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/10552, chr17-CpG: 15/Downstream/55422

Nearest cancer related gene

RPA1(TSG, No orient, 0)

Upstream sequence

tgtgcagttcttacatatgtatactgttaaatatatccctaaataatttacttttgaagcctggcacggtggctcacgcctgtaatcccagcactttttg

Downstream sequence

ggaggctgaggcgggcagatcaccagaggtcaggagtttgagaccagcctggccaacgtagtgaaaccctgtctctactaaaaatacaaaaattagccag