Basic Information
VIS ID
TVIS10010393
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
26
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCT| |GCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATC
Host Sequence
Chromosome
chr17
Cytoband
q22
Reference genome
GRCh37/hg19
Start
53816104/55738743 (Hg38)
End
53816104/55738743 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10226/Upstream/4970013; hsa-mir-1250/Downstream/1152527;
Nearest TSS
ENST00000595228/Upstream/6622; ENST00000576183/Downstream/12236;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/177140, chr17-CpG: 32/Downstream/12318
Nearby gene
TMEM100(-6622) ; PCTP(+12236) ;
Upstream sequence
TTAAATTTAAttttatatttttagagatgggtttcactctgtcacccacgctggcacaagcataactcattataacctccaattcctgggctcaagtgat
Downstream sequence
cctcctgcctcagcctcccaaatagctgggactatagacctgagccaccatgcctggcACAAAAAAGTATTTTTAAAATCCCCAAATAGATGCCCTTATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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