Basic Information
VIS ID
TVIS10010397
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
683
Orient
+
Integrated sequence
CGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACT| |AGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTG
Host Sequence
Chromosome
chr18
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
64326428/66659191 (Hg38)
End
64326428/66659191 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/8208033; hsa-mir-5011/Downstream/422393;
Nearest TSS
ENST00000575820/Upstream/55053; ENST00000581951/Downstream/825775;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/907787, chr18-CpG: 83/Downstream/856809
Nearby gene
CDH19(-55212) ; MIR5011(+422393) ;
Upstream sequence
tttgtttgtgaaaccatatggcattggcattttttggaagttcttaaactaagaattacatttctctaatagatatgggacaattccagttattcatttt
Downstream sequence
atcagttgattttgatagcttgtgttactcaaagagtaagtgtttaatttattggcatgcagcttctcatatttcctcACTGTTAAAAGGCCAATATAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate