Basic Information
VIS ID
TVIS10010399
Fusion event
HBV-LOC105372213 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
26
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCT| |GCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATC
Host Sequence
Chromosome
chr18
Cytoband
q23
Reference genome
GRCh37/hg19
Start
74439180/76727224 (Hg38)
End
74439180/76727224 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105372213
Nearest miRNA
hsa-mir-1-2/Upstream/3873842;
Nearest TSS
ENST00000575820/Upstream/37135; ENST00000583095/Downstream/78512;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/113099, chr18-CpG: 28/Downstream/60136
Nearby gene
LINC00908(-167396) ; ZNF236-DT(+67508) ;
Upstream sequence
ctccgtctccaaaagaaaaaaaaaagcagaaagaaaattagccaggcatggtggcgcacacctatagtcccagctatttgggaggctgaggcaggaggat
Downstream sequence
cacttgagcctgggatgtcgagactgcagtgagccatgttcatgccactgcactccagcctaggtgacagtgagaccctgcctcaaaacaaacaaaacaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate