Basic Information
VIS ID
TVIS10010413
Fusion event
HBV-EVA1A integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1731
Orient
-
Integrated sequence
ACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGA| |CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC
Host Sequence
Chromosome
chr2
Cytoband
p12
Reference genome
GRCh37/hg19
Start
75737187/75510061 (Hg38)
End
75737187/75510061 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
EVA1A
Nearest miRNA
hsa-mir-1285-2/Upstream/419147; hsa-mir-10b/Downstream/4139233;
Nearest TSS
ENST00000437798/Upstream/35608; ENST00000451622/Downstream/7911;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/309157, chr2-CpG: 23/Downstream/49942
Upstream sequence
AAAACAGCATATGACTAGTAGATGTTAAAGCTGGGTGACAGGTCTATTATACTTTTTGGTATTTTGTATATGTTTTTAATGTTCTGTAATAAAACACTTC
Downstream sequence
TATGAAATGACAGAGTTGATCTATACTTAGTTCTTAAGATCTTGGTTTCCTTTGGAAGGAGAAGGAGAATGTGATTATCAGGGGCATGAGCAAGTGTGAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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