Basic Information
VIS ID
TVIS10010415
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
268
Orient
+
Integrated sequence
ACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTT| |CTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGG
Host Sequence
Chromosome
chr20
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
29829484/31241681 (Hg38)
End
29829484/31241681 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/5033403; hsa-mir-1-1/Downstream/365505;
Nearest TSS
ENST00000382410/Upstream/879951; ENST00000400552/Downstream/15983;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/319133, chr20-CpG: 20/Downstream/233565
Nearby gene
MLLT10P1(-191346) ; DEFB115(+15983) ;
Upstream sequence
atggaatgcaatgcaatggaatgcaatggaatggaatggaatgcaatggaatggaatggaatggaatggaatggaatggaatggaatggaatggaatgca
Downstream sequence
atggaatggaatggaatggaatggaatggaatgcaatggaatggaatggaatgcaatggaatggaatggaatggaatggaatggaatggaatggaatgga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate