Basic Information
VIS ID
TVIS10010416
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1790
Orient
-
Integrated sequence
ACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGC| |ATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGG
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
52923426/54306887 (Hg38)
End
52923426/54306887 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/238402; hsa-mir-1-1/Downstream/3014615;
Nearest TSS
ENST00000382410/Upstream/98459; ENST00000491469/Downstream/168710;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/98378, chr20-CpG: 96/Downstream/168307
Nearby gene
PFDN4(-86934) ; DOK5(+168840) ;
Upstream sequence
gtcctttaaagtgaagtcaactgattggagatgttaactccttcaagtaccttcacaggaacacttagattagtgtttctaatgatagcctagctgggtt
Downstream sequence
gacattataaaactaaccatTGAAGTATCCTTTGGTTGTAAATTGTAGCACAGCTAATCAAACTAACTTCCTAATATTGGCTAAGGCCGactgagggtta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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