Basic Information
VIS ID
TVIS10010424
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
344
Orient
-
Integrated sequence
AGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAAC| |CTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTT
Host Sequence
Chromosome
chr3
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
110721031/111002184 (Hg38)
End
110721031/111002184 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/1399287; hsa-mir-12124/Downstream/1110617;
Nearest TSS
ENST00000440867/Upstream/108708; ENST00000478327/Downstream/67206;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1883942, chr3-CpG: 105/Downstream/69118
Nearby gene
LINC01205(-1507017) ; NECTIN3-AS1(+43132) ;
Upstream sequence
TTCAGTATGATGTAATATTATAGGTAATATTAGATTTAAAGGATTATTATTCCTGACAGAGTTTTAGAAAGTTTCCTGGCATATCCTGATATACATTATT
Downstream sequence
ccatttcttctgaaactattccaaacaatagaaaaagagggactcctccctaactcattttatgaggccaccatcatcctgataccaaaacatggcagag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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