Basic Information
VIS ID
TVIS10010427
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
26
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCT| |GCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATC
Host Sequence
Chromosome
chr3
Cytoband
q25.33
Reference genome
GRCh37/hg19
Start
159430419/159712630 (Hg38)
End
159430419/159712630 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
IQCJ-SCHIP1 ; SCHIP1
miRNAs that regulate target gene
hsa-mir-98-5p
Nearest miRNA
hsa-let-7g/Upstream/429896; hsa-mir-1224/Downstream/691958;
Nearest TSS
ENST00000440867/Upstream/438875; ENST00000639448/Downstream/51083;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/910090, chr3-CpG: 166/Downstream/50527
Upstream sequence
tataagaaaggggtccaatttctgtattctgcttatggctagccagttttcccagcaccatttattaaatagggaataatttccccattgtttgtttatg
Downstream sequence
acttgagcccaggagctgaaggctgcagtgaactatgatcatgccaccactttctagcctgagtgatggaAaaaggaaaggaaaggaagggaagggaaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate