VISDB Viral Integration Site DataBase

VIS ID

TVIS10010428

Fusion event

HBV-MCF2L2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

344

Orient

-

Integrated sequence

AGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAAC| |CTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTT

Chromosome

chr3

Cytoband

q27.1

Reference genome

Start

End

183063795/183346007 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-510-3p ; hsa-mir-6818-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-4738-3p ; hsa-mir-3923 ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-1273e ; hsa-mir-25-5p ; hsa-mir-7160-5p ; hsa-mir-658 ; hsa-mir-202-3p ; hsa-mir-4500 ; hsa-mir-98-5p ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-6087 ; hsa-mir-219b-3p ; hsa-mir-7162-3p ; hsa-mir-1247-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-6888-5p ; hsa-mir-302f ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-6883-5p ; hsa-mir-6799-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-383-3p ; hsa-mir-890 ; hsa-mir-6736-5p ; hsa-mir-4701-3p ; hsa-mir-1262 ; hsa-mir-7703 ; hsa-mir-500a-3p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-542-3p ; hsa-mir-661 ; hsa-mir-767-5p ; hsa-mir-6776-5p ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-6742-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-508-5p

Nearest miRNA

hsa-let-7g/Upstream/6830856; hsa-mir-1224/Downstream/540793;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/91160, chr3-CpG: 126/Downstream/81632

Upstream sequence

TGAGCAACGGCAAGAATAATTTAGCCAAGCGCCCAATGCTTATCTCCACAAGATCACAAAATCACTTCAAATAATGAAGACTTCTAGTTAAATACTTTTC

Downstream sequence

ccatttcttctgaaactattccaaacaatagaaaaagagggactcctccctagctcattttatgaggccagcatcatcctgataccaaaatctgacagag