Basic Information
VIS ID
TVIS10010429
Fusion event
HBV-NMRAL2P integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1639
Orient
-
Integrated sequence
ACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATA| |TTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGG
Host Sequence
Chromosome
chr3
Cytoband
q27.2
Reference genome
GRCh37/hg19
Start
185685568/185967779 (Hg38)
End
185685568/185967779 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA3C
Target gene
NMRAL2P
Nearest miRNA
hsa-let-7g/Upstream/199875; hsa-mir-1248/Downstream/818893;
Nearest TSS
ENST00000440867/Upstream/29643; ENST00000453370/Downstream/96781;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/29538, chr3-CpG: 126/Downstream/139894
Upstream sequence
TTTAGCCAAGCGCCCAATGCTTATCTCCACAAGATCACAAAATCACTTCAAATAATGAAGACTTCTAGTTAAATACTTTTCTCTCCTTTTTATGACATTA
Downstream sequence
gccaaggcaggtggatcacttgaggtcaggagttcgagaccagcctgaccaacatggcgaaactctgtatctactaaaaatacaaaatcagctgggtgca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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