Basic Information
VIS ID
TVIS10010441
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1125
Orient
-
Integrated sequence
CCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGT| |GTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGG
Host Sequence
Chromosome
chr4
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
29692228/29690606 (Hg38)
End
29692228/29690606 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA4D
Nearest miRNA
hsa-mir-12113/Upstream/870938; hsa-mir-1243/Downstream/6735760;
Nearest TSS
ENST00000502981/Upstream/476208; ENST00000507864/Downstream/1029809;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2828990, chr4-CpG: 55/Downstream/587493
Nearby gene
MIR4275(-870938) ; PCDH7(+1029802) ;
Upstream sequence
tgataggagcaccaaccctattataaactgcatgtggaagtgatctaggttgtgtgctccttatgagaatctaatgcctgatgatctgtcactgtttccc
Downstream sequence
tgagactccaactcagaaaaaaaGGTTCTTTGACCATGACTACCATAAGAACTAGAAGTGATATTTCATGTGAAATTACTGTTCATTATACCACTCTATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate