VISDB Viral Integration Site DataBase

VIS ID

TVIS10010452

Fusion event

HBV-CEP135 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

588

Orient

-

Integrated sequence

AGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGAC| |GGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGC

Chromosome

chr4

Cytoband

q12

Reference genome

Start

End

56895380/56029214 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-5010-3p ; hsa-mir-592 ; hsa-mir-3912-5p ; hsa-mir-4669 ; hsa-mir-3657 ; hsa-mir-4650-3p ; hsa-mir-4716-5p ; hsa-mir-4257 ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-4458 ; hsa-mir-98-5p ; hsa-let-7a-5p ; hsa-let-7b-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-let-7g-5p ; hsa-mir-4500 ; hsa-let-7i-5p ; hsa-let-7c-5p ; hsa-mir-4477a ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-6837-3p ; hsa-mir-216b-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-497-3p ; hsa-mir-5089-5p ; hsa-mir-6842-3p ; hsa-mir-4279 ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-6778-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-150-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6814-5p ; hsa-mir-5571-5p ; hsa-mir-4726-3p ; hsa-mir-466 ; hsa-mir-4699-3p ; hsa-mir-135b-5p ; hsa-mir-135a-5p ; hsa-mir-96-3p ; hsa-mir-2681-3p ; hsa-mir-1278 ; hsa-mir-1183 ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-6507-5p ; hsa-mir-361-3p

Nearest miRNA

hsa-mir-12113/Upstream/3316467; hsa-mir-1243/Downstream/4893405;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/79869, chr4-CpG: 80/Downstream/19742

Upstream sequence

tgctctgacttttataccaggtaacacaagagtcttccacctttgaataggacccaagcagaaaagggctctgtagcaACCCTATAGTCTCTAAAAATCT

Downstream sequence

gaaaggttcctgaacccagtttttggaggttttatgcaggtatcactaagtagatatgatcgattaaatcattagccattcatgatcaattcaaccttca