Basic Information
VIS ID
TVIS10010456
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
294
Orient
-
Integrated sequence
CGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACC| |GTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTT
Host Sequence
Chromosome
chr4
Cytoband
q21.23
Reference genome
GRCh37/hg19
Start
86160931/85239778 (Hg38)
End
86160931/85239778 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/2486348; hsa-mir-1243/Downstream/482690;
Nearest TSS
ENST00000502981/Upstream/273387; ENST00000505856/Downstream/235336;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/273154, chr4-CpG: 29/Downstream/235791
Nearby gene
WDFY3-AS2(-232763) ; ARHGAP24(+235353) ;
Upstream sequence
ccacggtaaagatccttcctctttgcagccgagaataatGagggttggggttagggttagggttagggtgagggtgagggtgagggtgagggtgagggtg
Downstream sequence
ccatttcttctgaaactattccaaacaatagaaaaagagggactcccccctaactcattttatgaggccagcatcatcgtgataccaaaacctggcagag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate