Basic Information
VIS ID
TVIS10010468
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
344
Orient
-
Integrated sequence
AGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAAC| |CTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTT
Host Sequence
Chromosome
chr5
Cytoband
q32
Reference genome
GRCh37/hg19
Start
146518108/147138545 (Hg38)
End
146518108/147138545 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/3458574; hsa-mir-103a-1/Downstream/1923768;
Nearest TSS
ENST00000502646/Upstream/53761; ENST00000503975/Downstream/96314;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/259533, chr5-CpG: 32/Downstream/96175
Nearby gene
PPP2R2B(-57075) ; STK32A(+96471) ;
Upstream sequence
TATCATTCCTTCCTCCACAGGAGTGAGAGGAACTCCTCTGCCCCTGGGGGGGGATAGGGAAGGGGCTCAATCCCAGTAGAGTAGGAGGGATGGACTTTAA
Downstream sequence
cagctcctctttgtacctctggtagtatttggctgtgaatctgtctggtcctggggtttttttggttgggaggctattaattactgccttagtttcagaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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