Basic Information
VIS ID
TVIS10010474
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr6
Cytoband
q27
Reference genome
GRCh37/hg19
Start
167831104/167417616 (Hg38)
End
167831104/167417616 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/419704; hsa-mir-4644/Downstream/2913145;
Nearest TSS
ENST00000381078/Upstream/33106; ENST00000597278/Downstream/261654;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/65980, chr6-CpG: 144/Downstream/3761
Nearby gene
TCP10(-33106) ; LINC01558(+354115) ;
Upstream sequence
ctcttatagcttctttttatgtcacttttcattctgttccagctatatggtacttgctatcttgcttttcctcaaatagtctggaaatgttcctacccta
Downstream sequence
CCGACCAGCAGTGTGAACACCATTCCTTTTCTTTTACAAAACTACCTTAACTCTTTATGGAATTTGCTTTTACCATTAGGAAAAATGTGGGTTTTTTAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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