Basic Information
VIS ID
TVIS10010476
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
344
Orient
-
Integrated sequence
AGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAAC| |CTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTT
Host Sequence
Chromosome
chr6
Cytoband
q12
Reference genome
GRCh37/hg19
Start
69247639/68537747 (Hg38)
End
69247639/68537747 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/11147535; hsa-mir-10524/Downstream/2839213;
Nearest TSS
ENST00000381078/Upstream/207848; ENST00000604969/Downstream/96577;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/2442809, chr6-CpG: 37/Downstream/97093
Nearby gene
ADGRB3(+97993) ;
Upstream sequence
TTACTCTGCTAAGCTAATATTTTCCAGATTCAGATTCTAAATTCAACAAGTTCAGTTACAATTATAATTCAGGTTTACATTTACTTGTTCAAAGAAAGAA
Downstream sequence
ccattccttctgaagctattccaaacaatagaaaaagagggactcctccctaactcattttgtgaggccagcatcaccctgataccaaaacctggcagag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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